手机版现金连环夺宝

当前位置:  首页 > 师资队伍 > 资深专家

李俊龙

李俊龙.jpg

    李俊龙,博士,特聘研究员,于2013年在四川大学华西药学院获理学博士学位。同年,在德国著名洪堡基金(Alexander von Humboldt fellowship)资助下,赴德国Westf?lische Wilhelms-Universit?t Münster有机化学研究所进行博士后研究;师从德国著名化学家Frank Glorius教授,开展卡宾小分子催化及可见光催化研究。相关科研成果分别发表在Acc. Chem. Res.、Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、Chem. Sci.等国际顶级学术期刊上。

 

 

研究方向:

1,手性药物及不对称催化合成
2,具有生理活性先导化合物发现

主讲课程:

《有机立体化学》


科研项目:
[1]. 2016/01-2019/12,国家自然科学基金青年项目,“新型手性三氮唑盐的设计合成及其在不对称氮杂环卡宾催化中的应用”,26.3万元,项目负责人
[2]. 2015/01-2016/12,中药资源系统研究与开发利用省部共建国家重点实验室培育基地开放基金,“基于不对称合成策略的新型头孢菌素开发研究”,10万元,项目负责人
[3]. 2016/01-2019/12,国家自然科学基金面上项目,“融合多层次化学结构特征研究钩吻中吲哚生物碱抗乳腺癌的构效关系和作用机制”,68.4万元,项目主研(排名第一)
[4]. 2015/05-2018/05,成都大学引进人才科研启动项目,“手性药物及绿色合成”,100万元,项目负责人


成果获奖及专利:
1, 2011年教育部博士学术新人奖
2,获国家授权发明专利一项“手性二氢色原酮骨架化合物及不对称合成”,授权专利号:ZL2011104204998.


代表性论文、论著:
1. Jun-Long Li, Basudev Sahoo, Constantin-G. Daniliuc, and Frank Glorius*, “Conjugate Umpolung of β,β-Disubstituted Enals via N-Heterocyclic Carbene and Br?nsted Acid Dual Catalysis: Facile Construction of Contiguous Quaternary Stereocenters”, Angew. Chem. Int. Ed. 2014, 53, 10515.
2. Jun-Long Li, Cai-Zhen Yue, Peng-Qiao Chen, You-Cai Xiao and Ying-Chun Chen*, “Remote Enantioselective Fri -Activation”, Angew. Chem. Int. Ed. 2014, 53, 5449.
3.Jun-Long Li, Tian-Yu Liu and Ying-Chun Chen*, “Aminocatalytic Asymmetric Diels-Alder Reactions via HOMO Activation”, Acc. Chem. Res. 2012, 45, 1491.
4. Jun-Long Li, Si-Li Zhou, Peng-Qiao Chen, Lin Dong, Tian-Yu Liu and Ying-Chun Chen*, “Asymmetric Diels–Alder Reaction of β,β-disubstituted Enals and Chromone-fused Dienes: Construction of Collections with High Molecular Complexity and Skeletal Diversity”, Chem. Sci. 2012, 3, 1879.
5. Jun-Long Li, Tai-Rang Kang, Si-Li Zhou, Rui Li, Li Wu, and Ying-Chun Chen*, “Organocatalytic Asymmetric Inverse Electron Demand Diels-Alder Reaction of Electron Deficient Dienes and Crotonaldehyde”, Angew. Chem. Int. Ed. 2010, 49, 6418. (Highlighted by Synfacts, 2010, 10, 1196.)
6. Jun-Long Li, Si-Li Zhou, Bo Han, Li Wu, and Ying-Chun Chen*, “Aminocatalytic Asymmetric Inverse-Electron-Demand Aza-Diels–Alder Reaction of N-Ts-1-aza-1,3-butadienes Based on Coumarin Cores”, Chem. Commun. 2010, 46, 2665.
7. Jun-Long Li, Bo Han, Kun Jiang, Wei Du, and Ying-Chun Chen*, “Organocatalytic Enantioselective Hetero-Diels–Alder Reaction of Aldehydes and o-Benzoquinone Diimide: Synthesis of Optically Active Hydroquinoxalines”, Bioorg. Med. Chem. Lett. 2009, 19, 3952. (Invited for a special issue: Tetrahedron Young Investigator Award 2009: C. F. Barbas, III)
8. Basudev Sahoo, Jun-Long Li and Frank Glorius*, “Visible-Light Photoredox-Catalyzed Semipinacol-Type Rearrangement: Trifluoromethylation/Ring Expansion via a Radical Polar Mechanism”, Angew. Chem. Int. Ed. 2015, in press, doi: 10.1002/anie.201503210.
9. Yuan Yao, Jun-Long Li, Qing-Qing Zhou, Lin Dong, and Ying-Chun Chen*, “Enantioselective Aza-Morita-Baylis-Hillman Reaction with Ketimines and Acrolein Catalyzed by Organic Assemblies”, Chem. Eur. J. 2013, 19, 9447.
10. Bo Han, Jun-Long Li, Chao Ma, Shan-Jun Zhang and Ying-Chun Chen*, “Organocatalytic Asymmetric Inverse Electron Demand Diels-Alder Reaction of N-Sulfony-1-Aza-1,3- butadienes and Aldehydes”, Angew. Chem. Int. Ed. 2008, 47, 9971. (This paper was selected as front cover story.)
11. Si-Li Zhou, Jun-Long Li, Lin Dong, and Ying-Chun Chen*, “Organocatalytic Sequential Hetero-Diels–Alder and Friedel–Crafts Reaction: Constructions of Fused Heterocycles with Scaffold Diversity”, Org. Lett. 2011, 13, 5874.
12. Bo Han, Jun-Long Li, You-Cai Xiao, Si-Li Zhou, and Ying-Chun Chen*, “Thiourea-Catalyzed Asymmetric Mannich-Type Reactions”, Curr. Org. Chem. 2011, 15, 4128.
13. Matthew N. Hopkinson, Basudev Sahoo, Jun-Long Li, and Frank Glorius* “ Dual Catalysis sees the Light: Combining Photoredox with Organo-, Acid, and Transition-Metal Catalysis” Chem. Eur. J. 2014, 20, 3874.
14. Bo Han, Zhao-Quan He, Jun-Long Li, Rui Li, Kun Jiang, Tian-Yu Liu and Ying-Chun Chen*, “Organocatalytic Regio- and Stereoselective Inverse-Electron-Demand Aza-Diels–Alder Reaction of alfa,beta-Unsaturated Aldehydes and N-Tosyl-1-aza-1,3-butadienes”, Angew. Chem. Int. Ed. 2009, 48, 5474. (Highlighted by Synfacts, 2009, 9, 968.)
15. Zhi-Jun Jia, Hao Jiang, Jun-Long Li, Bjorn Gschwend, Qing-Zhu Li, Xiang Yin, Julie Grouleff, Ying-Chun Chen* and Karl Anker J?rgensen*, “Trienamines in Asymmetric Organocatalysis: DielsAlder and Tandem Reactions”, J. Am. Chem. Soc. 2011, 133, 5053. (Highlighted by Synfacts, 2011, 12, 1385.)

 

?